Depression, Depressionen

Vagus Nerve Anatomy:

The NTS relays tVagus Nerve Stimulation: his incoming sensory information to the rest of the brain through three main pathways: 1) an autonomie feedback loop, 2) direct projections to the reticular formation in the medulla, and 3) ascending projections to the forebrain largely through the parabrachial nucleus (PB) and the locus ceruleus (LC). The PB sits adjacent to the LC (one of the prirnary norepinephrine containing areas of the brain: Figure 2).

In fact, lesioning the LC in rats eliminates the ability of VNS to suppress seizures (Krahl et al 1998), demonstrating how important this connection is for the antiepileptic action of VNS (Figure 2).