Erkrankungen der Sinne.
News v. 1.4.4.
Erkrankungen der Sinne.
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- Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes 18.05.2006 240.00 Uhr
- Background: The autism spectrum encompasses a set of complex multigenic developmental disorders that severely impact the development of language, non-verbal communication, and social skills, and are associated with odd, stereotyped, repetitive behavior and restricted interests. To date, diagnosis of these neurologically...more..
- Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity 28.04.2006 436.00 Uhr
- IntroductionIncreased mammographic density is a strong risk factor for breast cancer. The reasons for this are not clear; two obvious possibilities are increased epithelial cell proliferation in mammographically dense areas and increased breast epithelium in women with mammographically dense breasts. We addressed this...more..
- Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo 12.04.2006 436.00 Uhr
- IntroductionThe ras pathway is essential for cell growth and proliferation. The effects of R115777, a farnesyl transferase inhibitor, were investigated in cancer cell lines expressing varying levels of growth factor receptors and with differing ras status. Effects on tumour xenografts and human ductal carcinoma in situ...more..
- Tumor-specific expression of ?v?3 integrin promotes spontaneous metastasis of breast cancer to bone 11.04.2006 436.00 Uhr
- IntroductionStudies in xenograft models and experimental models of metastasis have implicated several ?3 integrin-expressing cell populations, including endothelium, platelets and osteoclasts, in breast tumor progression. Since orthotopic human xenograft models of breast cancer are poorly metastatic to bone and experimental...more..
- HER4 in breast cancer: comparison of antibodies against intra- and extra-cellular domains of HER4 07.04.2006 436.00 Uhr
- IntroductionWe have previously linked HER4 expression with increased survival in breast cancer. However, other reports have associated HER4 with adverse prognostic significance. One possible explanation for the conflicting reports may be that these results are antibody dependent. The HER4 protein is enzymatically cleaved,...more..
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